| 產(chǎn)品編號 | bsm-61403R |
| 英文名稱 | AAT Recombinant Rabbit mAb |
| 中文名稱 | α-1抗胰蛋白酶重組兔單抗 |
| 別 名 | Serpin A1; Short peptide from AAT; SPAAT; AAT. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-2000,ICC/IF=1:50-200,IP=1:20-50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測分子量 | 51 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Antithrombin 3: 1-418 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. SWISS: P01009 Gene ID: 5265 α1-抗胰蛋白酶（A1AT）缺乏是最常見的遺傳代謝病，能引起肺和肝的損傷。α1抗胰蛋白酶為呼吸系統(tǒng)的非特異性可溶因子，與呼吸道抵抗力關(guān)系密切，它可抑制多種酶的活性，包括細(xì)菌的酶，以及中性白細(xì)胞溶酶體分泌的蛋白酶、彈性蛋白酶、膠原酶、纖維蛋白溶酶和凝血酶。α1抗胰蛋白酶的缺乏與慢性阻塞性肺病的形成關(guān)系密切，因?yàn)樗娜狈?，不能及時(shí)控制感染和炎癥產(chǎn)生的多種蛋白酶，而造成肺組織破壞。 α1-抗胰蛋白酶由肝細(xì)胞產(chǎn)生,是一種分子量為45-56kDa的糖蛋白,它能抑制蛋白酶、彈性蛋白酶、膠原酶等多種水解酶的活性。 |
| 產(chǎn)品圖片 |
Western blot analysis of human fetal kidney lysate. Using AAT (bsm-61403R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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