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LRIG2 Rabbit pAb (bs-1845R)  
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產(chǎn)品編號 bs-1845R
英文名稱 LRIG2 Rabbit pAb
中文名稱 LRIG2抗體
別    名 DKFZp451C181; KIAA0806; LIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 precursor; LRIG2_HUMAN; UFS2; LIG-2.  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  信號轉(zhuǎn)導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Dog,GuineaPig,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 117 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LRIG2: 701-800/1065 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 LRIG2 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG2 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Tissue Specificity:
Detected in all tissues analyzed.

Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 15 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

SWISS:
O94898

Gene ID:
9860

Database links:

Entrez Gene: 9860 Human

Omim: 608869 Human

SwissProt: O94898 Human

Unigene: 448972 Human



LRIG1屬于LRIGs基因家族。LRIGs是新發(fā)現(xiàn)的一類基因,在哺乳動物體內(nèi)廣泛存在,目前發(fā)現(xiàn)該家族至少包括三個成員:LRIG1、LRIG2和LRIG3,是一類結(jié)構(gòu)相似的跨膜糖蛋白,該蛋白人、鼠的同源性較高。
目前在腫瘤方面的研究較多,有研究認為:LRIG1是通過下調(diào)EGFR的表達來抑制其下游重要信號傳導通路的激活而發(fā)揮抑癌作用,LRIG1在抑制腫瘤轉(zhuǎn)移中具有重要作用。
產(chǎn)品圖片
Sample: Lymph node (Mouse) Lysate at 40 ug Primary: Anti- LRIG2 (bs-1845R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 117 kD Observed band size: 117 kD
Sample: Lane 1: Human HeLa cell lysates Lane 2: Human HepG2 cell lysates Primary: Anti-LRIG2 (bs-1845R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 117 kDa Observed band size: 117 kDa
Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti- LRIG2 (bs-1845R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 117 kD Observed band size: 117 kD
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