| 產(chǎn)品編號(hào) | IHC0506 |
| 英文名稱 | SATB2 Ready-To-Use IHC Kit |
| 中文名稱 | DNA結(jié)合蛋白2即用型免疫組化試劑盒 |
| 別 名 | GLSS; KIAA1034; SATB2; DNA binding protein SATB2; SATB homeobox 2 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI). SWISS: Q9UPW6 Gene ID: 23314 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Mouse brain tissue slide using IHC0506 (SATB2 Kit).
Immunohistochemical analysis of paraffin embedded Human gastric cancer tissue slide using IHC0506 (SATB2 Kit).
Immunohistochemical analysis of paraffin embedded Human brain tissue slide using IHC0506 (SATB2 Kit).
Immunohistochemical analysis of paraffin embedded Rat brain tissue slide using IHC0506 (SATB2 Kit).
|
