| 產(chǎn)品編號(hào) | IHC0506H |
| 英文名稱 | Human SATB2 Ready-To-Use IHC Kit |
| 中文名稱 | 人DNA結(jié)合蛋白2即用型免疫組化試劑盒 |
| 別 名 | GLSS; KIAA1034; SATB2; DNA binding protein SATB2; SATB homeobox 2 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI). SWISS: Q9UPW6 Gene ID: 23314 |
| 產(chǎn)品圖片 |
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Immunohistochemical analysis of paraffin embedded Human colon cancer tissue slide using IHC0506H (Human SATB2 Kit).
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