| 產(chǎn)品編號(hào) | IHC0509H |
| 英文名稱 | Human ZAP70 Ready-To-Use IHC Kit |
| 中文名稱 | 人zeta相關(guān)蛋白70即用型免疫組化試劑盒 |
| 別 名 | ADMIO2; IMD48; mrtle; mur; SRK; STCD; STD; TZK; ZAP-70; ZAP70 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling. SWISS: P43403 Gene ID: 7535 |
| 產(chǎn)品圖片 |
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Immunohistochemical analysis of paraffin embedded Human lymph nodes tissue slide using IHC0509H (Human ZAP70 Kit).
Immunohistochemical analysis of paraffin embedded Human tonsil tissue slide using IHC0509H (Human ZAP70 Kit).
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