| 產(chǎn)品編號 | IHC0510R |
| 英文名稱 | Rat XBP1 Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠細(xì)胞核轉(zhuǎn)錄因子X盒結(jié)合蛋白即用型免疫組化試劑盒 |
| 別 名 | D11Ertd39e; HTF; TREB-5; TREB5; XBP-1; XBP1; XBP2 |
| 克 隆 號 | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. SWISS: P17861 Gene ID: 7494 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Rat liver tissue slide using IHC0510R (Rat XBP1 Kit).
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