| 產(chǎn)品編號(hào) | IHC0545R |
| 英文名稱 | Rat Thymidylate synthase Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠胸苷酸合成酶即用型免疫組化試劑盒 |
| 別 名 | HST422; OK/SW-cl.29; TMS; TS; TYMS |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. SWISS: P04818 Gene ID: 7298 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Rat spleen tissue slide using IHC0545R (Rat Thymidylate synthase Kit).
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