| 產(chǎn)品編號(hào) | IHC0569H |
| 英文名稱 | Human LRP1 Ready-To-Use IHC Kit |
| 中文名稱 | 人低密度脂蛋白受體相關(guān)蛋白1即用型免疫組化試劑盒 |
| 別 名 | A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5; KPA; LDL receptor related protein 1 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes. SWISS: Q07954 Gene ID: 4035 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human placenta tissue slide using IHC0569H (Human LRP1 Kit).
Immunohistochemical analysis of paraffin embedded Human brain tissue slide using IHC0569H (Human LRP1 Kit).
Immunohistochemical analysis of paraffin embedded Human testis tissue slide using IHC0569H (Human LRP1 Kit).
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