| 產(chǎn)品編號(hào) | IHC0587R |
| 英文名稱(chēng) | Rat GCS beta 1 Ready-To-Use IHC Kit |
| 中文名稱(chēng) | 大鼠鳥(niǎo)苷酸環(huán)化酶β1即用型免疫組化試劑盒 |
| 別 名 | GC-S-beta-1; GC-SB3; GCbeta1; GUC1B3; GUCB3; GUCSB3; GUCY1B1; GUCY1B3; SGC; GCS-beta-1; GCS-beta-3 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load. SWISS: Q02153 Gene ID: 2983 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Rat heart tissue slide using IHC0587R (Rat GCS beta 1 Kit).
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