| 產(chǎn)品編號 | IHC0600 |
| 英文名稱 | eIF3A Ready-To-Use IHC Kit |
| 中文名稱 | 真核翻譯起始因子3A即用型免疫組化試劑盒 |
| 別 名 | A830012B05Rik; Csma; EIF3; eIF3-p170; eIF3-theta; EIF3A; EIF3S10; KIAA0139; mKIAA0139; P167; p180; p185; TIF32; ZH12 |
| 克 隆 號 | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). SWISS: Q14152 Gene ID: 8661 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Mouse brain tissue slide using IHC0600 (eIF3A Kit).
Immunohistochemical analysis of paraffin embedded Human brain tissue slide using IHC0600 (eIF3A Kit).
Immunohistochemical analysis of paraffin embedded Rat brain tissue slide using IHC0600 (eIF3A Kit).
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