| 產(chǎn)品編號(hào) | IHC0641R |
| 英文名稱 | Rat ZO-1 Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠胞質(zhì)緊密粘連蛋白1/閉鎖小帶蛋白1即用型免疫組化試劑盒 |
| 別 名 | TJP1; ZO-1; ZO1; Tight junction protein 1; Tight junction protein ZO 1; ZO 1; Zona occludens protein 1; Zonula occludens protein 1 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome. SWISS: Q07157 Gene ID: 7082 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Rat kidney tissue slide using IHC0641R (Rat ZO-1 Kit).
|
